Research Publications

Transition-metal and photocatalyst-free oxidative cleavage of aryl alkynes with PIDA/iminoiodinanes in visible light, Rajat, and N. Jain*, Org. Biomol. Chem., 23, 10363-10369 (2025).

Photocatalyzed synthesis of coumarin-3-derivatives from aryl alkynoates and hydrazines, Harsha, Rohit Kumar, and N. Jain*, J. Org. Chem., 90, 13047-13055 (2025).

Base-assisted orthogonal synthesis of 4-arylisoquinolinediones and azanaphthoquinones from 2-alkynylarylnitriles via photoactivation by pyrylium salt in visible light, Shruti Rajput, and N. Jain*, Adv. Synth. Catal., 367, e70062 (2025).

Dual ipso-hydroxylation and para-C-H chalcogenation of arylboronic acids using NDI photocatalyst in visible light, A. Datta, and N. Jain*, Chem. Commun., 61, 8536-8539 (2025).

Photoredox assisted net-neutral radical-polar crossover α-acylation of enol acetates with acyl chlorides: Access to 1,3-diketones, R. Kumar, Harsha, and N. Jain*, Adv. Synth. Catal., 367, e202500007 (2025).

2-oxo-2H-chromen-7-olate catalyzed C–C and C–N Bond Formations in Visible Light, V. Dixit, S. Sharma, and N. Jain*, Asian J. Org. Chem., e202400684 (2025).

Synthesis of aminated C-3 aryloylated benzofuran, furopyridine, benzothiophene and indole derivatives from 1,6-enyne and N-aminopyridinium salt in visible light, S. Rajput, Rajat, Nitesh, P. Gupta, H. Singh, and N. Jain*, J. Org. Chem., 90, 493-502 (2025).

End cap effect on solution-processable deep blue lasing materials with low-amplified spontaneous emission thresholds, Y. Sugai, V. P. Rahane, I. Gale, C. Verdi, A. R. Ireland, S. Canola, S. K. M. McGregor, E. G. Moore, N. Jain, E. B. Namdas, and S.-C. Lo,* ACS Appl. Mater. & Interfaces, 16, 46506−46515 (2024).

Highly stable red emissive organic semiconductor materials with low amplified spontaneous emission thresholds, V. P. Rahane, R. B. Roseli, A. R. Ireland, I. Gale, A. Shukla, E. G. Moore, E. H. Krenske, E. B. Namdas,* N. Jain,* and S.-C. Lo,* Adv. Optical Mater., 2400892 (2024).

Low amplified spontaneous emission threshold from solution processable excited-state intramolecular proton transfer chromophores, V. P. Rahane, A. Shukla, R. B. Roseli, A. R. Ireland, I. Gale, E. H. Krenske, E. G. Moore, E. B. Namdas,* N. Jain,* and S.-C. Lo, ,* Adv. Optical Mater., 2400840 (2024).

Photocatalyst-free regioselective sulfonamidation of N-(2-hydroxyaryl)amides in visible-light, Rajat, S. Rajput, N. Grover, and N. Jain*, Org. Biomol. Chem., 22, 8649-8655 (2024).

1O2 and base assisted oxidative conversion of mediated conversion of b-Enaminoesters to α-Acyloxy-b-ketoesters under Visible Light Irradiation, R. Kumar, Deepak, and N. Jain*, J. Org. Chem., 89, 14472-14482 (2024).

Oxidative organic transformations photocatalyzed by NDI in visible light, A. Datta, Ritu, S. Kumar, S. Chorol, P. Mukhopadhyay, and N. Jain*, Org. Lett., 26, 35, 7357-7362 (2024).

1O2 mediated synthesis of carbonyl substituted quinoline-2,4(1H,3H)-diones in visible light: 4CzIPN as a reusable photocatalyst, Harsha, R. Kumar, and N. Jain*, Chem. Commun., 60, 5646-5649 (2024).

1O2 mediated conversion of b-enaminonitriles to a-keto amides photosensitized by recyclable H2TPP in visible light, R. Kumar, N. Grover, and N. Jain*, J. Org. Chem., 89, 4722−4732 (2024).

Photoredox radical cascade cyclization of 2-alkynylarylnitriles in visible light: Direct access to 3-Amino-1-indenones, S. Rajput, D. Garg, and N. Jain*, Adv. Synth. Catal., 366, 2072-2078 (2024)

Light blue rigid excited-state intramolecular proton transfer organic semiconductor laser chromophores, I. Allison, M. Mamada, A. Shukla, S.K.M. McGregor, R.B. Roseli, I. Gale, V.P. Rahane, E.G. Moore, E.H. Krenske, N. Jain, C. Adachi, E.B. Namdas, S.-C. Lo,* J. Mat. Chem. C, 11, 15861-15872 (2023).
Visible light-mediated, acid-catalyzed, C-N cross dehydrogenative coupling of quinoxalin-2(1H)-ones with carbazoles and amides: Access to fluorescent probes featuring aggregate induced emission, V. Dixit, Pooja, and N. Jain*, Adv. Synth. Catal., 365, 4684-4691 (2023).
Photoredox/Palladium dual catalysis for site-selective C−H arylation and acylation of N‑protected carbazoles in visible light, Rajat, and N. Jain*, J. Org. Chem., 88, 8600-8608 (2023).
Photo-induced functionalization of para-benzoquinones: Access to dihydroquinoxalines with a tetrasubstituted carbon stereocenter, V. Dixit, A. Sharma, A. Jangid, and N. Jain*, Adv. Synth. Catal., 365, 1-9 (2023).
Synthesis of linear enamides and enecarbamates via photoredox acceptorless dehydrogenation, Ritu, D. Kolb, N. Jain*, and B. Konig, Adv. Synth. Catal., 365, 605-611 (2023).

Ru, Rh and Ir catalyzed enantioselective sp3 C-H functionalization, R. Kaur, and N. Jain*, Chemistry-An Asian J., 17, e202200944 (2022).
Visible light catalyzed photoredox hydroxy-arylation of terminal double bond of N- substituted-3-methylene isoindolin-1-ones, R. Kumar, V. Kumar, and N. Jain*, J. Org. Chem., 87, 11939-11946 (2022).
Photocatalyzed dehydrogenation of aliphatic N-heterocycles releasing dihydrogen, Ritu, S. Das, Y.-M. Tian, T. Karl, N. Jain, B, Konig, ACS Catal., 12, 10326-10332 (2022).
Selectfluor mediated tandem fluorination and 1,3-carbonyl migration in ortho- carbonyl anilines: Charge transfer enabled ortho-selectivity, A. Garia, S. Kumar, and N. Jain*, Asian J. Org. Chem., 11, 6, e202200164 (2022).
Pd and photoredox dual catalysis assisted decarboxylative ortho-benzoylation of N- phenyl-7-azaindoles, S. Rajput, R. Kaur, and N. Jain*, Org. Biomol. Chem., 20, 1453-1461 (2022).
Book Chapter: Copper-catalysed sp2 C-H bond functionalization, R. Kaur, A. Sharma, and N. Jain, Handbook of CH-Functionalization, Wiley-VCH (2022).

Insights of ligand binding in modeled h5-HT1A receptor: homology modeling, docking, MM-GBSA, screening and molecular dynamics, P. Jha, S. Chaturvedi, R. Bhat, N. Jain, and A.K. Mishra, J. Biomol. Str. Dyn., 1-13 (2021).
Metal-free synthesis of anthranils by PhIO mediated heterocyclization of ortho-carbonyl anilines, A. Garia, J. Grover, and N. Jain*, Eur. J. Org. Chem., 29, 3936-4242 (2021).
Photoredox halogenation of quinolones: the dual role of halo-fluorescein dyes. Ritu, S. Kumar, P. Chauhan, and N. Jain*, Org. Biomol. Chem., 18, 2921-2928 (2021).
Visible light mediated in situ generation of disubstituted p-quinone methides: Construction of a sterically congested quaternary stereocenter. A. Sharma, V. Dixit, S. Kumar, and N. Jain*, Org. Lett., 23, 3409-3414 (2021).
Quinoline fused lactones via tandem oxidation cyclization: metal-free sp3 C-H functionalization. A. Garia, P. Chauhan, R. Halder, and N. Jain*, J. Org. Chem., 86, 538-546 (2021).

Fast transfer hydrogenation(TH) in aerobic condition and oxidation of alcohols with N-Methylmorpholine-N-oxide catalyzed by Ru(II) ligated with chalcogenated pyridines and PPh3. R. Kumar, V. V. Singh, N. Jain, and A.K. Singh, Chemistry Select, 5, 9572-9578 (2020).
Photoinitiated Thiol-Ene Reactions of Various 2,3-Unsaturated O-,C- S- and N- Glycosides-Scope and Limitations Study. V. Kelemen, M. Csavas, J. Hotzi, M. Herczeg, Poonam, B. Rathi, P. Herczegh, N. Jain, and A. Borbas, Chemistry-An Asian J., 15, 876-891 (2020).
Singlet oxygen mediated dual C-C and C-N bond cleavage in visible light. Ritu, C. Sharma, S. Kumar, and N. Jain*, Org. Biomol. Chem., 18, 2921-2928 (2020).
Zinc Triflate Catalyzed 1,3-Indolylation of Cyclohexanones: Tandem Condensation, Dehydrogenation and Aromatization Sequence. H. Singh, R. Tiwari, P. Sharma, P. Kumar, and N. Jain*, Org. Biomol. Chem., 18, 2492-2500 (2020).

Acetylated Benzothiazolone as Homobivalent SPECT metallo-radiopharmaceutical 99mTc-(6-AcBTZ)2DTPA: Design, Synthesis and Pre-clinical evaluation for mapping 5-HT1A/7 receptors. P. Jha, S. Chaturvedi, Anju, A. Kaul, N. Jain, and A. K. Mishra, ACS Omega, 4, 6, 10044-10055 (2019).
Compounds based on 5-(perylen-3-ylethynyl)uracil scaffold: high activity against tick-borne encephalitis virus and non-specific activity against enterovirus A., A.A. Chistov, A.A. Orlov, P.P. Steshnev, N.A. Slesarchuk, I.O. Aparin, B. Rathi, V.A. Brylev, S.V. Kutyakov, I.V. Mikhura, A.V. Ustinov, G. Westman, V.A. Palyulin, N. Jain, D.I. Osolodkin, L.I. Kozlovskaya, and V.A. Korshun, Eur. J. Med. Chem., 171, 93-103 (2019).
S-Aryl Arenesulfonothioate and Copper Acetate Mediated Arylthiolation of 2-Aryl Pyridines and Heteroarenes. P. Sharma, and N. Jain*, J. Org. Chem., 84, 13045- 13052 (2019).
Transition metal-free synthesis of fused quinazolinones by oxidative cyclization of N- pyridylindoles. A. Garia, and N. Jain*, J. Org. Chem., 84, 9661-9670 (2019).
Oxidative C-C bond formation and C-N bond cleavage catalyzed by complexes of copper(I) with acridine based (E N E) pincers (E = S/Se), recyclable as a catalyst. S. Gupta P. Dubey, A.K. Singh, N. Jain*, Dalton Trans., 48, 10129-10137 (2019).
Metal-free and visible light promoted C-3 thiocyanation of 2-arylquinolin-4-ones. P. Chauhan, Ritu, Preeti, S. Kumar, and N. Jain*, Eur. J. Org. Chem., 4334-4340 (2019).

Design, Physico-chemical and Pre-clinical evaluation of homo-bivalent 99mTc- (BTZ)2DTPA radio-ligand for dimeric 5-HT1A/5-HT7 Receptors. P.Jha, S. Chaturvedi, A. Kaul, P. Pant, S. Pal, N. Jain, and A. K. Mishra, New J. Chem., 42, 15032-15043 (2018).
Chemoselective synthesis of N-arylbenzamides and benzoyloxyacetanilides from aryl isocyanides: Styrene as aryl and arylcarboxymethylene source. P. Sharma, and N. Jain*, Adv. Synth. Catal., 360, 1932-1937 (2018).
GO-Cu7S4 catalyzed ortho-aminomethylation of phenol derivatives with N,N- dimethylbenzylamines: Site-selective oxidative CDC. S. Gupta, N. Chandna, P. Dubey, A. K. Singh, and N. Jain*, Chem. Commun., 54, 7511-7514 (2018).
Regioselective synthesis of N2-alkylated-1,2,3 triazoles and N1-alkylated benzotriazoles: Cu2S as a recyclable nanocatalyst for oxidative amination of N,N- dimethylbenzylamines. S. Gupta, N. Chandna, A. K. Singh, and N. Jain*, J. Org. Chem., 83, 3226-3235 (2018).

Improvising 5-HT7R homology model for design of high affinity ligands: Model validation with molecular dynamic simulations, embrace minimization and docking studies, P. Jha, S. Chaturvedi, Swastika, N. Jain, and A. K. Mishra, J. Biomol. Structure & Dynamics, 2475-2494 (2017).
Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure. M.S. Deshmukh, and N. Jain*, ACS Med. Chem. Lett., 8, 1153-1158 (2017).
Glucose promoted facile reduction of azides to amines in aqueous alkaline conditions. N. Chandna, F. Kaur, S. Kumar, and N. Jain*, Green Chem., 19, 4268-4271 (2017).
2,2’-homocoupled azine N,N’-dioxides or azine N-oxides: CDC or SNAr controlled chemoselectivity. A. K. Jha, and N. Jain*, Eur. J. Org. Chem., 4765-4772 (2017).
Iodine catalyzed C-N bond formation: Synthesis of 3-Aminoquinoxalinones under ambient conditions. A. Gupta, M. S. Deshmukh, and N. Jain*, J. Org. Chem., 82 (9), 4784–4792 (2017).
N-Mannich bases of aromatic heterocyclic amides: Synthesis via copper catalyzed aerobic cross-dehydrogenative coupling under ambient conditions. S. K. Singh, N. Chandna, and N. Jain*, Org. Lett., 19, 1322-1325 (2017).
Palladium catalyzed carbonylative coupling for synthesis of aryl ketones and aryl esters using chloroform as the carbon monoxide source. P. Sharma, S. Rohilla, and N. Jain*, J. Org. Chem., 82 (2), 1105-1113 (2017).

Copper-catalyzed anti-Markovnikov hydroindolation of terminal alkynes: Regioselective synthesis of bis(indolyl)alkanes. A. Srivastava, S. S. Patel, N. Chandna, and N. Jain*, J. Org. Chem., 81 (23), 11664-11670 (2016).
Nitrogen and sulphur functionalized graphene oxide-palladium nanoparticle hybrid catalyst for an efficient Heck coupling. C. Premi, and N. Jain*, RSC Adv., 6, 74961–74967 (2016).
Regioselective ortho-acylation of N-aryl-1,2,3-triazoles with alcohols in water. C. Premi, S. S. Patel, and N. Jain*, Eur. J. Org. Chem., 423, 3788-3795 (2016).
Cu6Se4.5 Nanoparticles from a Single Source Precursor: Recyclable and Efficient Catalyst for Cross-Dehydrogenative Coupling of Tertiary Amines with Terminal Alkynes. S. Gupta, H. Joshi, N. Jain*, and A. K. Singh*, J. Mol. Cat. A: Chem., 423, 135-142 (2016).
I2 mediated synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3H)-ones via sequential condensation/oxidative cyclization and rearrangement. S. S. Patel, N. Chandna, S. Kumar, and N. Jain*, Org. Biomol. Chem., 14, 5683-5689 (2016).
Graphene oxide decorated with Cu(I)Br nanoparticles: A reusable catalyst for the synthesis of potent bis(indolyl)methane based anti-HIV drugs. A. Srivastava, A. Agarwal, S. K. Gupta, and N. Jain*, RSC Adv., 6, 23008-23011 (2016).
Copper acetate catalysed regioselective synthesis of substituted 1,2,3-triazoles: A versatile azide-alkene cycloaddition/oxidation approach. S. Rohilla, S. S. Patel, and N. Jain*, Eur. J. Org. Chem., 847-854 (2016).
Microwave-assisted ortho-alkylation of azine N-oxides with N-tosylhydrazones catalyzed by copper(I) iodide. A. K. Jha, and N. Jain*, Chem. Commun., 52, 1831- 1834 (2016).

Curcumin binds to the pre-fibrillar aggregates of Cu/Zn Superoxide Dismutase (SOD1) and alters its amyloidogenic pathway resulting in reduced cytotoxicity. N. K. Bhatia, A. Srivastava, N. Katyal, N. Jain, A. M. Khan, B. Kundu, and S. Deep, BBA-Proteins and Proteomics, 426-436 (2015).
One-pot sequential alkynylation and cycloaddition: Regioselective construction and biological evaluation of novel benzoxazole-triazole derivatives. A. Srivastava, L. Aggarwal, and N. Jain*, ACS Combinatorial Science, 17, 39-48, (2015).
D-Glucosamine as a green ligand for Pd catalyzed cross-coupling of aryl and heteroaryl halides. A.K. Jha, R. Shahani, and N. Jain*, Synlett, 26, 259-264 (2015).
Pd/Mannose promoted tandem cross coupling-nitro reduction: Expedient synthesis of aminobiphenyls and aminostilbenes. S. Rohilla, P. Pant, and N. Jain*, RSC Adv., 5, 31311-31317 (2015).
Copper acetate-DMSO promoted methylthiolation of arenes and heteroarenes. P. Sharma, S. Rohilla, and N. Jain*, J. Org. Chem., 80 (8), 4116-4122 (2015).
Palladium catalyzed regioselective decarboxylative alkylation of arenes and heteroarenes with aliphatic carboxylic acids. C. Premi, A. Dixit, and N. Jain*, Org. Lett., 17, 2598-2601 (2015).
Aryl alkyl carbene-Pd complex assisted C-Cl bond activation: An unprecedented cross-coupling route to trans-stilbenes. A. K. Jha, S. Kishor and N. Jain*, RSC Adv., 5, 55218-55226 (2015).
Zinc triflate catalyzed C-benzylation: Chemo- and regioselective route to amido substituted diaryl and arylheteroarylmethanes. M. S. Deshmukh, A. Srivastava, B. Das, and N. Jain*, J. Org. Chem., 80 (20), 10041-10048 (2015).

Improving the anticancer activity of curcumin using nanocurcumin dispersion in water. R. Khosla, R. Basniwal, and N. Jain*, Nutrition and Cancer, 66 (6), 1015- 1022, (2014).
Dual SNAr reaction in activated ortho-halonitrobenzene: Direct synthesis of substituted 1,2,3,4-tetrahydroquinoxalines, 2,3-dihydro-1,4-benzoxazines, and 1,4- benzodioxines. M. Deshmukh, B. Das, and N. Jain*, RSC Adv., 3, 22389-22396 (2013).
Phosphane-free Hiyama cross-coupling of aryl and heteroaryl halides catalyzed by palladium nanoparticles in ionic liquids. C. Premi, and N. Jain*, Eur. J. Org. Chem., 24, 5493-5499 (2013).
Synthesis of glucose-tagged triazolium ionic liquids and their application as solvent and ligand for copper (I) catalyzed amination. A. K. Jha, and N. Jain*, Tetrahedron Lett., 54, 4738-4741 (2013).
Ethylacetoacetate tagged basic imidazolium salt: multi-task in CuI catalyzed amination of aryl halides. A. Srivastava, and N. Jain*, Tetrahedron, 69, 5092-5097 (2013).
Nanocurcumin: preparation, characterization, and antimicrobial study. Bhawana, R. Basniwal, H. S. Buttar, V.K. Jain, and N. Jain*, J. Agr. Food Chem., 59, 2056-2061 (2011).
Plant-biomass and nanomaterial-based composites for removal of dyes from wastewater. N. Jain, R. K. Basniwal, Suman, A.K. Srivastava, and V.K. Jain, Environmental Tech., 31, 755-760 (2010).
Influence of flanking sequence context on the conformational flexibility of aminofluorene-modified dG adduct in dA mismatch DNA duplexes. N. Jain, S. Meneni, V. Jain, and B.P. Cho, Nucleic Acids Res., 37, 1628-1637 (2009).
Methylene-2’-deoxynucleoside 5’-triphosphate as non-cleavable substrates for DNA polymerases: Isolation, characterization, and stability studies of novel 2’- deoxycyclonucleosides,3,5’-anhydro-dG and 2,5’-anhydro-dT. N. Jain, F. Liang, T. Hutchens, D. D. Shock, W. A. Beard, S. H. Wilson, M. P. Chiarelli, and B. P. Cho, J. Med. Chem., 51 (20), 6460-6470, (2008).
Fluorescence probing of aminofluorene-induced conformational heterogeneity in DNA duplexes. N. Jain, Y.K. Reshetnyak, L. Gao, M.P. Chiarelli, and B.P. Cho, Chem. Res. Toxicol., 21 (2), 445-452, (2008).
Probing the sequence effects on NarI-Induced -2 frameshift mutagenesis by dynamic 19F NMR, UV, and CD spectroscopy. N. Jain, Y. Li, L. Zhang, S.R. Meneni, and B.P. Cho, Biochemistry, 46, 13310-13321, (2007).
Biomimetic oxidation of veratryl alcohol with H2O2 catalyzed by iron(III) porphyrins and HRP in ionic liquid. A. Kumar, N. Jain, and S.M.S. Chauhan, Synlett, 411-414, (2007).
Synthesis of transition metal porphyrins from free-base 5,10,15,20- tetraarylporphyrins under microwave irradiation in ionic liquids. N. Jain, A. Kumar, and S.M.S. Chauhan, Synth. Commun., 35 (9), 1223-1230, (2005).
Metalloporphyrin and heteropoly acid catalyzed oxidation of C=NOH bonds in ionic liquids: Biomimetic models of Nitric Oxide Synthase. N. Jain, A. Kumar, and S.M.S. Chauhan, Tetrahedron Lett., 46 (15), 2599-2602, (2005).
Chemical and biochemical transformations in ionic liquids. N. Jain, A. Kumar, S. Chauhan, and S.M.S. Chauhan, Tetrahedron, 61 (5), 1015-1060, (2005).
Microwave assisted dealkylation of alkyl aryl ethers in ionic liquids. N. Jain, and S.M.S. Chauhan, J. Chem. Res., 10, 693-694, (2004).
Ytterbium(III) Triflate catalyzed conversion of carbonyl compounds into 1,3- oxathiolanes in ionic liquids. A. Kumar, N. Jain, S. Rana, and S.M.S. Chauhan, Synlett, 15, 2785-2787, (2004).
Oxidation of benzylic alcohols to carbonyl compounds with potassium permanganate in ionic liquids. A. Kumar, N. Jain, and S.M.S. Chauhan, Synth. Commun., 34 (15), 2835-2842, (2004).
Biomimetic oxidation of curcumin with hydrogen peroxide catalyzed by 5,10,15,20- tetraaryl porphyrinato(III) chlorides in dichloromethane. S.M.S. Chauhan, K.A. Srinivas, N. Jain, and A. Kumar, Chem. Pharm. Bull., 51 (11), 1345-1347, (2003).
Copper (I) chloride catalyzed synthesis of diaryl ethers in ionic liquids under mild conditions. S.M.S. Chauhan, N. Jain, A. Kumar, and K.A. Srinivas, Synth. Commun., 33 (20), 3607-3614, (2003).

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